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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Allosterism at Muscarinic Receptors: Ligands and Mechanisms

Author(s): N. J.M. Birdsall and S. Lazareno

Volume 5, Issue 6, 2005

Page: [523 - 543] Pages: 21

DOI: 10.2174/1389557054023251

Price: $65


The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.

Keywords: muscarinic receptors, allosterism, cooperativity, enhancers, receptor models, structure-activity relationships, interaction studies, receptor subtype selectivity

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