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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Chemotherapy of Chagas Disease: An Overview

Author(s): M. Paulino, F. Iribarne, M. Dubin, S. Aguilera-Morales, O. Tapia and A. O.M. Stoppani

Volume 5, Issue 5, 2005

Page: [499 - 519] Pages: 21

DOI: 10.2174/1389557053765565

Price: $65


The review presents: a) a brief description of the disease; b) a summary of the most important metabolic targets so far identified in Trypanosome cruzi (T. cruzi) along with corresponding inhibitor compounds; c) the current state of knowledge on the trypanothione reductase system of trypanosomatids with reference to oxidative stress defenses; d) detailed discussions on T. cruzi trypanothione reductase inhibitors such as nitrofuranes, naphthoquinones and phenothiazines. As yet, the chemotherapy of Chagas disease remains an unsolved problem. Further search for new drugs must continue by means of nucleating existing chemotherapy efforts.

Keywords: antichagasic agents, chemotherapy targets, trypanosomiasis, trypanothione metabolism, trypanothione reductase inhibitors

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