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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review

Author(s): Thomas Scior, Antonio Guevara-Garcia, Philippe Bernard, Quoc-Tuan Do, David Domeyer and Stefan Laufer

Volume 5, Issue 11, 2005

Page: [995 - 1008] Pages: 14

DOI: 10.2174/138955705774575264

Price: $65


Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.

Keywords: vanadium, anti-diabetic, insulin-mimetic, phospho-mimetic, ptp-1b, toxicity, molecular design

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