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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Albumin Nanoparticles for the Intravitreal Delivery of Anticytomegaloviral Drugs

Author(s): J. M. Irache, M. Merodio, A. Arnedo, M. A. Camapanero, M. Mirshahi and S. Espuelas

Volume 5, Issue 3, 2005

Page: [293 - 305] Pages: 13

DOI: 10.2174/1389557053175335

Price: $65

Abstract

Albumin nanoparticles (NP) were proved to be effective and safe carriers for delivering anticytomegaloviral compounds in the vitreous. NP improved the antiviral activity of both ganciclovir and the phosphodiester oligonucleotide analog to formivirsen. NP appeared to be fusogenic carriers able to target the nucleus of cells. In addition, these drug carriers were well tolerated when administered by the intravitreal route and did not induce autoimmune reactions.

Keywords: albumin, nanoparticles, ganciclovir, fomivirsen, oligonucleotides, intravitreal delivery, retinitis


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