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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of Its Enantiomer

Author(s): D. Belotti, J. L. Peglion and J. Cossy

Volume 2, Issue 7, 2005

Page: [634 - 636] Pages: 3

DOI: 10.2174/157017805774297019

Price: $65

Abstract

Y-27632 and its enantiomer were synthesized in 8 steps from trans-1,4-cyclohexanedicarboxylic acid by using a diastereoselective reductive amination of a ketone.

Keywords: kinase inhibitor, rho-associated kinase, reductive amination


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