Abstract
Expressed protein ligation has become a frequently used technique to insert non-standard amino acids into proteins. The technique has been adapted to insert selenocysteine residues in place of cysteine residue in proteins, taking advantage of the similarity in the chemistries of sulfur and selenium. This replacement can confer unique structural and catalytic properties to enzymes and proteins. The development of this technique also allows for naturally occurring selenoproteins to be produced semisynthetically.
Keywords: selenocysteine, expressed protein ligation, thioredoxin reductase, semisynthetic
Protein & Peptide Letters
Title: Incorporation of Selenocysteine into Proteins Using Peptide Ligation
Volume: 12 Issue: 8
Author(s): Robert J. Hondal
Affiliation:
Keywords: selenocysteine, expressed protein ligation, thioredoxin reductase, semisynthetic
Abstract: Expressed protein ligation has become a frequently used technique to insert non-standard amino acids into proteins. The technique has been adapted to insert selenocysteine residues in place of cysteine residue in proteins, taking advantage of the similarity in the chemistries of sulfur and selenium. This replacement can confer unique structural and catalytic properties to enzymes and proteins. The development of this technique also allows for naturally occurring selenoproteins to be produced semisynthetically.
Export Options
About this article
Cite this article as:
Hondal J. Robert, Incorporation of Selenocysteine into Proteins Using Peptide Ligation, Protein & Peptide Letters 2005; 12 (8) . https://dx.doi.org/10.2174/0929866054864319
DOI https://dx.doi.org/10.2174/0929866054864319 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Non-Lipid Effects of Statins: Emerging New Indications
Current Vascular Pharmacology Induction of Myocardial Fibrosis and Hypertrophy by Natriuretic Peptides
Vascular Disease Prevention (Discontinued) Value of Carnitine Therapy in Kidney Dialysis Patients and Effects on Cardiac Function from Human and Animal Studies
Current Drug Targets Biomarkers as a Guide of Medical Treatment in Cardiovascular Diseases
Current Medicinal Chemistry Life-history Constraints on the Mechanisms that Control the Rate of ROS Production
Current Genomics Animal Models Used for the Evaluation of Antiretroviral Therapies
Current HIV Research Water Soluble Vitamins and their Role in Diabetes and its Complications
Current Diabetes Reviews Annexin A5 Imaging: An Academic Research – Clinical Trials and Theses
Current Molecular Imaging (Discontinued) LCHAD and MTP Deficiencies - Two Disorders of Mitochondrial Fatty Acid β-Oxidation with Unusual Features
Current Pediatric Reviews Lipids, Statins and Heart Failure: An Update
Current Pharmaceutical Design Therapeutic Effects of Renal Denervation on Renal Failure
Current Neurovascular Research Flavones as a Privileged Scaffold in Drug Discovery: Current Developments
Current Organic Synthesis Biomarkers in Acute Heart Failure Syndromes: An Update
Current Cardiology Reviews In Silico Approach to Finding New Active Compounds from Histone Deacetylase (HDAC) Family
Current Pharmaceutical Design Endotherapia
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Targeting Calcium and the Mitochondria in Prevention of Pathology in the Heart
Current Drug Targets Adverse Bioeffects of Ultrasound Contrast Agents Used in Echocardiography: True Safety Issue or “Much Ado About Nothing”?
Current Vascular Pharmacology Caveolin-3: Its Importance in Muscle Function and Pathology
Current Genomics MicroRNA-130a Regulation of Desmocollin 2 in a Novel Model of Arrhythmogenic Cardiomyopathy
MicroRNA Impact of Aging on the Angiogenic Potential of the Myocardium: Implications for Angiogenic Therapies with Emphasis on Sirtuin Agonists
Recent Patents on Cardiovascular Drug Discovery