Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies

Title: Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies

Volume: 2 Issue: 4

Author(s): Claudio Olea-Azar, Carolina Rigol, Fernando Mendizabal, Hugo Cerecetto, Rossanna Di Maio, Mercedes Gonzalez, Williams Porcal, Antonio Morello, Yolanda Repetto and Juan Diego Maya

Affiliation:

Keywords: oxadiazole n-oxide, trypanosoma cruzi, cyclic voltammetry, esr spectroscopy, cellular respiration

Abstract: In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic voltammetry and electron spin resonance spectroscopy were used to predict the bio-reduction processes. Effects on the parasitic respiration were studied.

Cite this article as:

Olea-Azar Claudio, Rigol Carolina, Mendizabal Fernando, Cerecetto Hugo, Maio Di Rossanna, Gonzalez Mercedes, Porcal Williams, Morello Antonio, Repetto Yolanda and Maya Diego Juan, Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies, Letters in Drug Design & Discovery 2005; 2 (4) . https://dx.doi.org/10.2174/1570180054038341