Medicinal Chemistry, Metabolic Profiling and Drug Target Discovery: A Role for Metabolic Profiling in Reverse Pharmacology and Chemical Genetics

George   G.   Harrigan; Daniel   J.   Brackett; Laszlo   G.   Boros

Abstract

Comprehensive analysis of the metabolome can contribute to mechanism of action studies for small molecules discovered in phenotypic screens. Examples are presented in this overview of the rapidly developing field of “metabolic profiling.” These examples include the use of NMR in gene function analysis, GC-based studies on the identification of metabolic pathways affected by PPAR-γ agonists, applications of Fourier-transform MS and the use of stable isotope-based metabolic profiling (SIDMAP) to investigate metabolic adaptive changes induced by effective anticancer agents.

Keywords: chemical genetics, reverse pharmacology, metabolic profiling, metabolic fingerprinting, metabonomics, metabolomics, sidmap

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Mini-Reviews in Medicinal Chemistry

Title: Medicinal Chemistry, Metabolic Profiling and Drug Target Discovery: A Role for Metabolic Profiling in Reverse Pharmacology and Chemical Genetics

Volume: 5 Issue: 1

Author(s): George G. Harrigan, Daniel J. Brackett and Laszlo G. Boros

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Keywords: chemical genetics, reverse pharmacology, metabolic profiling, metabolic fingerprinting, metabonomics, metabolomics, sidmap

Abstract: Comprehensive analysis of the metabolome can contribute to mechanism of action studies for small molecules discovered in phenotypic screens. Examples are presented in this overview of the rapidly developing field of “metabolic profiling.” These examples include the use of NMR in gene function analysis, GC-based studies on the identification of metabolic pathways affected by PPAR-γ agonists, applications of Fourier-transform MS and the use of stable isotope-based metabolic profiling (SIDMAP) to investigate metabolic adaptive changes induced by effective anticancer agents.

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Harrigan G. George, Brackett J. Daniel and Boros G. Laszlo, Medicinal Chemistry, Metabolic Profiling and Drug Target Discovery: A Role for Metabolic Profiling in Reverse Pharmacology and Chemical Genetics, Mini-Reviews in Medicinal Chemistry 2005; 5 (1) . https://dx.doi.org/10.2174/1389557053402800

DOI https://dx.doi.org/10.2174/1389557053402800	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607

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