Abstract
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.
Keywords: Privileged structures, pharmacophoric point, rational drug design, bioactive N-acylhydrazones derivatives
Mini-Reviews in Medicinal Chemistry
Title: Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates
Volume: 7 Issue: 11
Author(s): Carolina D. Duarte, Eliezer J. Barreiro and Carlos A.M. Fraga
Affiliation:
Keywords: Privileged structures, pharmacophoric point, rational drug design, bioactive N-acylhydrazones derivatives
Abstract: Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.
Export Options
About this article
Cite this article as:
Duarte D. Carolina, Barreiro J. Eliezer and Fraga A.M. Carlos, Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates, Mini-Reviews in Medicinal Chemistry 2007; 7 (11) . https://dx.doi.org/10.2174/138955707782331722
DOI https://dx.doi.org/10.2174/138955707782331722 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Current Prevention and Treatment of Postoperative Nausea and Vomiting after Gynecological Laparoscopic Surgery
Current Drug Therapy Targeted Taxane Delivery Systems: Recent Advances
Drug Delivery Letters Laparoscopic Reconstructive Surgery in Pediatric Urology: An Overview of Current Options
Current Pediatric Reviews Epithelial Organotypic Cultures: A Viable Model to Address Mechanisms of Carcinogenesis by Epitheliotropic Viruses
Current Topics in Medicinal Chemistry Near Infrared Spectroscopy (NIRS) as a Tool to Analyze Phenolic Compounds in Plants
Current Analytical Chemistry Electroporation: An Effective Method For <i>In Vivo</i> Gene Delivery
Drug Delivery Letters Meet Our Editorial Board Member
Current Proteomics Food and Gastroesophageal Reflux Disease
Current Medicinal Chemistry Gold Nanoparticle Based Systems in Genetics
Current Pharmacogenomics Pollutants in Organic Chemistry and Medicinal Chemistry Education Laboratory. Experimental and Machine Learning Studies
Current Topics in Medicinal Chemistry Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis
Current Bioinformatics Oxytocin and Diabetes Mellitus: A Strong Biochemical Relation. Review
Current Diabetes Reviews Anthracyclines-Contra Cruciform Extrusion in DNA Regulating Sequences
Endocrine, Metabolic & Immune Disorders - Drug Targets Recent Developments and Applications of Derivative Spectrophotometry in Pharmaceutical Analysis
Current Pharmaceutical Analysis The Hormetic Role of Dietary Antioxidants in Free Radical-Related Diseases
Current Pharmaceutical Design Therapeutic Potential of Melatonin in the Regulation of MiR-148a-3p and Angiogenic Factors in Breast Cancer
MicroRNA The Diversity of Epithelial Secreted Mucins
Current Organic Chemistry In Vitro Cytotoxicity Evaluation of Some Substituted Indazole Derivatives
Letters in Drug Design & Discovery Prediction of Activities of BRAF (V600E) Inhibitors by SW-MLR and GA-MLR Methods
Current Computer-Aided Drug Design Protein NMR-Based Screening in Drug Discovery
Current Pharmaceutical Design