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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Antibacterial Activity of 3-Substituted Pyrrole-2,5-diones Against Pseudomonas Aeruginosa

Author(s): Eric Lattmann, Simon Dunn, Suwanna Niamsanit, Jintana Sattayasai and Nison Sattayasai

Volume 4, Issue 7, 2007

Page: [513 - 519] Pages: 7

DOI: 10.2174/157018007781788570

Price: $65


3-Substituted pyrrole-2,5-diones were synthesised from mucohalogen acids and the antibacterial activity was subsequently determined in biological assays. The minimum inhibitory concentration and the minimum bactericidal concentration of 2a were determined for a wide range of microorganisms in the low micromolar range. Protein identification using SDS-PAGE and LC/MS/MS demonstrated a partly degradation of OprF-related proteins giving an insight into the underlying mechanism of these novel antibacterial agents.

Keywords: Halogenated pyrrole, Antibacterial, Pseudomonas aeruginosa, OprF-related protein

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