Abstract
The epithelium and the mesenchyme comprise the two important cellular partitions found in virtually every organ, and one influence the other via paracrine and cell-cell interactions. These epithelial-mesenchymal interactions have been shown to play important roles for normal tissue development during embryogenesis, and also exert crucial roles in the adult, being involved in roles as diverse as mammary gland development to skin homeostasis and repair. Studies have revealed that pathological disorders in these interactions may result in fibrogenesis and carcinogenesis, and a number of in vitro and in vivo models have been developed and employed to specifically investigate the epithelial-mesenchymal interactions in these scenarios. A thorough understanding of the roles of epithelial-mesenchymal interactions in tissue repair, fibrogenesis and carcinogenesis will facilitate and define the appropriate treatment for tissue fibrotic and carcinogenic states.
Keywords: extracellular matrix, matrix metalloproteinase, interleukin, insulin-like growth factor, Keloid-derived fibroblasts
Current Signal Transduction Therapy
Title: The Role of Epithelial-Mesenchymal Interactions in Tissue Repair, Fibrogenesis and Carcinogenesis
Volume: 2 Issue: 3
Author(s): D. V. Do, A. Mukhopadhyay, I. J. Lim and T. T. Phan
Affiliation:
Keywords: extracellular matrix, matrix metalloproteinase, interleukin, insulin-like growth factor, Keloid-derived fibroblasts
Abstract: The epithelium and the mesenchyme comprise the two important cellular partitions found in virtually every organ, and one influence the other via paracrine and cell-cell interactions. These epithelial-mesenchymal interactions have been shown to play important roles for normal tissue development during embryogenesis, and also exert crucial roles in the adult, being involved in roles as diverse as mammary gland development to skin homeostasis and repair. Studies have revealed that pathological disorders in these interactions may result in fibrogenesis and carcinogenesis, and a number of in vitro and in vivo models have been developed and employed to specifically investigate the epithelial-mesenchymal interactions in these scenarios. A thorough understanding of the roles of epithelial-mesenchymal interactions in tissue repair, fibrogenesis and carcinogenesis will facilitate and define the appropriate treatment for tissue fibrotic and carcinogenic states.
Export Options
About this article
Cite this article as:
Do V. D., Mukhopadhyay A., Lim J. I. and Phan T. T., The Role of Epithelial-Mesenchymal Interactions in Tissue Repair, Fibrogenesis and Carcinogenesis, Current Signal Transduction Therapy 2007; 2 (3) . https://dx.doi.org/10.2174/157436207781745346
DOI https://dx.doi.org/10.2174/157436207781745346 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Transmembrane Protein 166 and its Significance
Protein & Peptide Letters The Molecular Basis of Herpesviruses as Oncolytic Agents
Current Pharmaceutical Biotechnology Extracellular Citrate in Health and Disease
Current Molecular Medicine Advances in peptidic and peptidomimetic-based approaches to inhibit STAT signaling in human diseases
Current Protein & Peptide Science Antibody Targeting of TGF-β in Cancer Patients
Current Pharmaceutical Biotechnology Vaccine Adjuvants: Key Tools for Innovative Vaccine Design
Current Topics in Medicinal Chemistry Detection and Specific Targeting of Hypoxic Regions within Solid Tumors: Current Preclinical and Clinical Strategies
Current Medicinal Chemistry Management of Gene Variants of Unknown Significance: Analysis Method and Risk Assessment of the VHL Mutation p.P81S (c.241C>T)
Current Genomics Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer
Current Drug Research Reviews Challenges for Drug Discovery - A Case Study of Urokinase Receptor Inhibition
Combinatorial Chemistry & High Throughput Screening Application of Radiolabeled Antibodies in Targeting Therapy of Breast Cancer
Current Molecular Imaging (Discontinued) Novel Histone Deacetylase Inhibitors for the Treatment of Pediatric Brain Tumors
Central Nervous System Agents in Medicinal Chemistry Matching Chelators to Radiometals for Positron Emission Tomography Imaging- Guided Targeted Drug Delivery
Current Drug Targets Exploiting Cyclooxygenase-(in)Dependent Properties of COX-2 Inhibitors for Malignant Glioma Therapy
Anti-Cancer Agents in Medicinal Chemistry Targeting Translation for Treatment of Cancer - A Novel Role for IRES?
Current Cancer Drug Targets Polyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis
Mini-Reviews in Medicinal Chemistry Minimally Invasive Transoral Surgical Treatment for Oropharyngeal Carcinoma
Current Cancer Therapy Reviews Array-Based Approaches for the Identification of Epigenetic Silenced Tumor Suppressor Genes
Current Genomics Apigenin Inhibits Proliferation, Migration, and Invasion of Human Tongue Carcinoma Tca8113 Cells Through Regulating the MAPK Signaling Pathways
Current Molecular Medicine Bacteria and Bacterial Toxins as Therapeutic Agents for Solid Tumors
Current Cancer Drug Targets