Abstract
This mini-review outlines recent (until the end of 2006) key developments in the use of β-cyclodextrin as a catalyst in organic synthesis. β-cyclodextrin is a water soluble supramolecular catalyst especially useful for transformations such as oxirane ring-opening, aziridine oxidation of alcohols, hydrolysis of phosphate esters and amidation of acids. It has been used for the selective synthesis of 2,6- naphthalene dicarboxylic acid, introduction of protecting groups and for ester cleavage. Interestingly, it has also been used in the aza- Michael addition of amines to conjugated alkenes, in photo-Reimer-Tiemann reactions and as a phase transfer catalyst.
Keywords: β-cyclodextrin, oxidation and reduction, protection and deprotection, phase transfer catalyst, aqueous medium
Mini-Reviews in Organic Chemistry
Title: β-Cyclodextrin as a Catalyst in Organic Synthesis
Volume: 4 Issue: 3
Author(s): Sheshanath Vishwanath Bhosale and Sidhanath Vishwanath Bhosale
Affiliation:
Keywords: β-cyclodextrin, oxidation and reduction, protection and deprotection, phase transfer catalyst, aqueous medium
Abstract: This mini-review outlines recent (until the end of 2006) key developments in the use of β-cyclodextrin as a catalyst in organic synthesis. β-cyclodextrin is a water soluble supramolecular catalyst especially useful for transformations such as oxirane ring-opening, aziridine oxidation of alcohols, hydrolysis of phosphate esters and amidation of acids. It has been used for the selective synthesis of 2,6- naphthalene dicarboxylic acid, introduction of protecting groups and for ester cleavage. Interestingly, it has also been used in the aza- Michael addition of amines to conjugated alkenes, in photo-Reimer-Tiemann reactions and as a phase transfer catalyst.
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Cite this article as:
Sheshanath Vishwanath Bhosale and Sidhanath Vishwanath Bhosale , β-Cyclodextrin as a Catalyst in Organic Synthesis, Mini-Reviews in Organic Chemistry 2007; 4 (3) . https://dx.doi.org/10.2174/157019307781369922
DOI https://dx.doi.org/10.2174/157019307781369922 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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