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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Mild Synthesis of Nitriles by TPPX2-promoted Dehydration of Primary Amides

Author(s): Daniele Vaccari, Paolo Davoli, Maria Bucciarelli, Alberto Spaggiari and Fabio Prati

Volume 4, Issue 5, 2007

Page: [319 - 321] Pages: 3

DOI: 10.2174/157017807781212157

Price: $65


An expeditious route to nitriles via dehydration of primary amides using halotriphenoxy phosphonium halides (TPPX2, X = Cl or Br) is described. The reaction proceeds under very mild conditions and allows the preparation of aromatic and aliphatic nitriles in good to excellent yields.

Keywords: Dehydration, dehydrohalogenation, halotriphenoxy phosphonium halides, imidoyl halides, nitriles, phosphonium salts

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