Abstract
The catalytic regions of Protein Kinases are known to have similarity in primary chains. However, it is not known whether there is a signature profile specific to a particular catalytic region? Whether the signature profile, if any, is unique to a protein kinases family in a particular species or in a group of species? We have attempted analyzing some of these aspects by statistical data mining using an authentic and exhaustive database of Protein Kinases. The results reveal interesting features and provide some new directions to look at their applications.
Keywords: Protein Kinase, Catalytic Sub Domain, Sequence Homology, BLAST, 2-way ANOVA, Statistical Likelihood Estimates
Protein & Peptide Letters
Title: Statistics of Catalytic Domain Sequences in Protein Kinases Vs Non-Kinases
Volume: 14 Issue: 6
Author(s): Rajani R. Joshi and Chaithanya Manda
Affiliation:
Keywords: Protein Kinase, Catalytic Sub Domain, Sequence Homology, BLAST, 2-way ANOVA, Statistical Likelihood Estimates
Abstract: The catalytic regions of Protein Kinases are known to have similarity in primary chains. However, it is not known whether there is a signature profile specific to a particular catalytic region? Whether the signature profile, if any, is unique to a protein kinases family in a particular species or in a group of species? We have attempted analyzing some of these aspects by statistical data mining using an authentic and exhaustive database of Protein Kinases. The results reveal interesting features and provide some new directions to look at their applications.
Export Options
About this article
Cite this article as:
Rajani R. Joshi and Chaithanya Manda , Statistics of Catalytic Domain Sequences in Protein Kinases Vs Non-Kinases, Protein & Peptide Letters 2007; 14 (6) . https://dx.doi.org/10.2174/092986607780989985
DOI https://dx.doi.org/10.2174/092986607780989985 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A New Role for Zn(II) Aminopeptidases: Antigenic Peptide Generation and Destruction
Current Pharmaceutical Design Regulatory Mechanism miR-302a-3p/E2F1/SNHG3 Axis in Nerve Repair Post Cerebral Ischemic Stroke
Current Neurovascular Research Vitamins in the Prevention or Delay of Cognitive Disability of Aging
Current Aging Science Targeted Cancer Therapeutics: Biosynthetic and Energetic Pathways Characterized by Metabolomics and the Interplay with Key Cancer Regulatory Factors
Current Pharmaceutical Design Tubulin-Targeting Agents in Hybrid Drugs
Current Medicinal Chemistry Chemical Constituents and Bioactivities of the Plants of Genus Flemingia Roxb. et Ait. (Leguminosae)
Combinatorial Chemistry & High Throughput Screening Mapping the Technological Knowledge Landscape: The Case of Epigenetics
Recent Patents on Anti-Cancer Drug Discovery Leukotriene A4 Hydrolase as a Target for Cancer Prevention and Therapy
Current Cancer Drug Targets Personalizing Medicine from Birth: Are Countries Prepared for the Ethical, Legal, and Social Challenges?
Current Pharmacogenomics and Personalized Medicine Metalloporphyrins Immobilized on Silica and Modified Silica as Catalysts in Heterogeneous Processes
Current Organic Synthesis Butyrate and Colorectal Cancer: The Role of Butyrate Transport
Current Drug Metabolism What Counselors Tell Low-Risk Clients About HIV Test Performance
Current HIV Research Gene Expression Profiling Analysis to Identify Key Genes and Underlying Mechanisms in Meniscus of Osteoarthritis Patients
Combinatorial Chemistry & High Throughput Screening Military Risk Factors for Cognitive Decline, Dementia and Alzheimer’s Disease
Current Alzheimer Research Differential Role of Apoptosis and Autophagy Associated with Anticancer Effect of Lupulone (Hop β-Acid) Derivatives on Prostate Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Bilosomes: A Novel Approach to Meet the Challenges in Oral Immunization
Recent Patents on Drug Delivery & Formulation Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats
Drug Metabolism Letters SCYPPred: A Web-Based Predictor of SNPs for Human Cytochrome P450
Protein & Peptide Letters Potential Biomarkers for Depression Associated with Coronary Artery Disease: A Critical Review
Current Molecular Medicine Library of Synthetic Compounds Based on Pyrazole Unit: Design and Screening Against Breast and Colorectal Cancer
Letters in Drug Design & Discovery