Generic placeholder image

Current Psychiatry Reviews


ISSN (Print): 1573-4005
ISSN (Online): 1875-6441

Bupropion HCL and Sleep in Patients with Depression

Author(s): Andrew D. Krystal, Michael E. Thase, Vivian L. Tucker and Elizabeth P. Goodale

Volume 3 , Issue 2 , 2007

Page: [123 - 128] Pages: 6

DOI: 10.2174/157340007780599096

Price: $65


Objectives: Depressed patients often have insomnia, daytime sleepiness, and/or changes in sleep architecture. These sleep/wake changes are associated with diminished quality of life, impaired function, diminished treatment response and greater risk of relapse. Antidepressants may cause, exacerbate, or ameliorate these sleep/wake alterations. The sleep/wake effects of bupropion, a norepinephrine/ dopamine reuptake inhibitor (NDRI), are relatively less well established. We carried out this literature review in order to characterize the sleep/wake effects of bupropion, provide an understanding of the antidepressant mechanisms involved and discuss implications for clinical practice. Methods: Manuscripts were identified using PubMed. In addition, reports were selected from references in the original search and reports concerning bupropion extended-release were provided by the manufacturer. Results: Bupropion was not associated with daytime sedation. Sleep disturbance occurs at a low rate, comparable to other modern reuptake inhibitors. Unlike other antidepressants, bupropion does not suppress REM sleep nor increase the risk of periodic leg movement disorder. Conclusion: Bupropion has a unique sleep/wake profile, which may be particularly well-suited for treatment of individuals suffering from depression accompanied by significant fatigue/sleepiness. A lack of REM suppression, which likely reflects bupropions NDRI mechanism of action, is also distinctive and does not affect antidepressant efficacy.

Keywords: Antidepressants, sleep electroencephalogram, REM sleep, insomnia, sedation, periodic leg movements

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy