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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

New Synthesis of 3-Aryl Isoquinolines by Pd-Catalyzed Suzuki Cross-Coupling

Author(s): Marco Franceschin, Stefano Frasca, Antonello Alvino and Armandodoriano Bianco

Volume 4, Issue 2, 2007

Page: [86 - 91] Pages: 6

DOI: 10.2174/157017807780414217

Price: $65


A new synthetic approach to 3-aryl isoquinolines, based on the Pd-catalyzed Suzuki cross-coupling reaction, is reported. The described procedure represents an efficient method to prepare 3-aryl isoquinolines by reaction of a preformed 3-chloro isoquinoline with a phenylboronic acid, especially when the nitrogen atom is positively charged.

Keywords: Suzuki cross-coupling, Pd catalysis, 3-aryl isoquinolines

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