Abstract
There is a close relationship among the types of sleep apnea (central, obstructive, and mixed) in regard to both the pathogenesis and in the clinical management of sleep apnea syndromes. This review will recount the rationale for the use of animal models in understanding intermediate traits, such as the ventilatory responses to hypoxia and reoxygenation, seen with human sleep apnea. One feature of particular interest will be the dynamic responses of the control system, specifically the instability over time that could operate to produce repetitive apneas. The recurrent nature of clinically significant sleep apnea can be understood in terms of feedback control, or “loop gain”. We will discuss findings in a mouse model for recurrent apneas and propose that there exist genetic mechanisms that could determine loop gain in the respiratory control system.
Keywords: Sleep apnea, animal model, hypoxia, respiratory control
Current Respiratory Medicine Reviews
Title: Loop Gain and Sleep Disordered Breathing
Volume: 3 Issue: 1
Author(s): Kingman P. Strohl, Motoo Yamauchi and Thomas E. Dick
Affiliation:
Keywords: Sleep apnea, animal model, hypoxia, respiratory control
Abstract: There is a close relationship among the types of sleep apnea (central, obstructive, and mixed) in regard to both the pathogenesis and in the clinical management of sleep apnea syndromes. This review will recount the rationale for the use of animal models in understanding intermediate traits, such as the ventilatory responses to hypoxia and reoxygenation, seen with human sleep apnea. One feature of particular interest will be the dynamic responses of the control system, specifically the instability over time that could operate to produce repetitive apneas. The recurrent nature of clinically significant sleep apnea can be understood in terms of feedback control, or “loop gain”. We will discuss findings in a mouse model for recurrent apneas and propose that there exist genetic mechanisms that could determine loop gain in the respiratory control system.
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Cite this article as:
Strohl P. Kingman, Yamauchi Motoo and Dick E. Thomas, Loop Gain and Sleep Disordered Breathing, Current Respiratory Medicine Reviews 2007; 3 (1) . https://dx.doi.org/10.2174/157339807779941794
DOI https://dx.doi.org/10.2174/157339807779941794 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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