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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Novel One-Pot Synthesis of Amide Derivatives of Methylenebisphosphonate Utilizing the Mesyl Moiety as Leaving Group

Author(s): Jonna Jokiniemi, Markku Ahlgren and Jouko J. Vepsalainen

Volume 3, Issue 12, 2006

Page: [898 - 900] Pages: 3

DOI: 10.2174/157017806779467951

Price: $65


A novel one-pot synthesis was developed for the preparation of partial amide esters of (dichloromethylene)bisphosphonic acid from readily available tetramethyl ester with good selectivity and purity.

Keywords: Bisphosphonate, amide esters, selective synthesis, mesyl leaving group, amination

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