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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Advances in the Development of Agonists Selective for β1-Type Thyroid Hormone Receptor

Author(s): J. Malm, G. J. Grover and M. Farnegardh

Volume 7, Issue 1, 2007

Page: [79 - 86] Pages: 8

DOI: 10.2174/138955707779317885

Price: $65


This mini-review will provide an overview on the recent design principles and structure-activity-relationship of β-selective thyroid hormone receptor (TR) agonists. The prospects for the treatment of metabolic diseases as dyslipidemia with TRβ-selective ligands are considerable enough so as to avoid cardiovascular acceleration mediated through TRα.

Keywords: Nuclear hormone receptors, thyroid hormones receptors, thyroid hormones agonists, X-ray, metabolic rate, cholesterol, heart rate, structure-activity-relationship (SAR), beta-selective

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