Abstract
Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA nonsequence- specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.
Keywords: Neuronal tau, RNA, non-sequence-specific RNA-binding, electrostatic interaction, proline rich domain, microtubule binding domain
Protein & Peptide Letters
Title: The Proline-Rich Domain and the Microtubule Binding Domain of Protein Tau Acting as RNA Binding Domains
Volume: 13 Issue: 7
Author(s): Xing Sheng Wang, Dong Liang Wang, Jing Zhao, Mei Hua Qu, Xiao Hong Zhou, Hai Jin He and Rong Qiao He
Affiliation:
Keywords: Neuronal tau, RNA, non-sequence-specific RNA-binding, electrostatic interaction, proline rich domain, microtubule binding domain
Abstract: Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA nonsequence- specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.
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Cite this article as:
Wang Xing Sheng, Wang Dong Liang, Zhao Jing, Qu Mei Hua, Zhou Xiao Hong, He Hai Jin and He Rong Qiao, The Proline-Rich Domain and the Microtubule Binding Domain of Protein Tau Acting as RNA Binding Domains, Protein & Peptide Letters 2006; 13 (7) . https://dx.doi.org/10.2174/092986606777790566
DOI https://dx.doi.org/10.2174/092986606777790566 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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