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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

The Proline-Rich Domain and the Microtubule Binding Domain of Protein Tau Acting as RNA Binding Domains

Author(s): Xing Sheng Wang, Dong Liang Wang, Jing Zhao, Mei Hua Qu, Xiao Hong Zhou, Hai Jin He and Rong Qiao He

Volume 13, Issue 7, 2006

Page: [679 - 685] Pages: 7

DOI: 10.2174/092986606777790566

Price: $65

Abstract

Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA nonsequence- specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.

Keywords: Neuronal tau, RNA, non-sequence-specific RNA-binding, electrostatic interaction, proline rich domain, microtubule binding domain


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