Inhibition of Hypusine Biosynthesis in Plasmodium: A Possible, New Strategy in Prevention and Therapy of Malaria

Title: Inhibition of Hypusine Biosynthesis in Plasmodium: A Possible, New Strategy in Prevention and Therapy of Malaria

Volume: 6 Issue: 11

Author(s): A. Kaiser, D. Ulmer, T. Goebel, U. Holzgrabe, M. Saeftel and A. Hoerauf

Affiliation:

Keywords: Hypusine, dipyridyl-piperidone carbonic esters, antiplasmodial, initiation factor eIF-5A, deoxyhypusine synthase (DHS)

Abstract: The increasing drug resistance of malaria parasites against chemotherapeutics enforces new strategies in finding new drugs. Here, we describe a new class of compounds the piperidone 3-carboxylates which show an antiplasmodial effect in vitro and in vivo. This effect might be caused by inhibition of eukaryotic initiation factor (eIF-5A).

Cite this article as:

Kaiser A., Ulmer D., Goebel T., Holzgrabe U., Saeftel M. and Hoerauf A., Inhibition of Hypusine Biosynthesis in Plasmodium: A Possible, New Strategy in Prevention and Therapy of Malaria, Mini-Reviews in Medicinal Chemistry 2006; 6(11) . https://dx.doi.org/10.2174/138955706778742795