Generic placeholder image

Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Inhibition of Hypusine Biosynthesis in Plasmodium: A Possible, New Strategy in Prevention and Therapy of Malaria

Author(s): A. Kaiser, D. Ulmer, T. Goebel, U. Holzgrabe, M. Saeftel and A. Hoerauf

Volume 6, Issue 11, 2006

Page: [1231 - 1241] Pages: 11

DOI: 10.2174/138955706778742795

Price: $65


The increasing drug resistance of malaria parasites against chemotherapeutics enforces new strategies in finding new drugs. Here, we describe a new class of compounds the piperidone 3-carboxylates which show an antiplasmodial effect in vitro and in vivo. This effect might be caused by inhibition of eukaryotic initiation factor (eIF-5A).

Keywords: Hypusine, dipyridyl-piperidone carbonic esters, antiplasmodial, initiation factor eIF-5A, deoxyhypusine synthase (DHS)

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy