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Recent Patents on CNS Drug Discovery (Discontinued)


ISSN (Print): 1574-8898
ISSN (Online): 2212-3954

AMPA Receptor Antagonists: Potential Therapeutic Applications

Author(s): Henri Mattes, Kurt Lingenhoehl, Hans Kalkman, Yves Auberson, Johanne Renaud, Markus Schmutz and David Orain

Volume 1, Issue 3, 2006

Page: [247 - 259] Pages: 13

DOI: 10.2174/157488906778773698

Price: $65


The current review will focus on the recent patents for AMPA receptor antagonists and their claims, evidence for their therapeutic effectiveness in the treatment of epilepsy and their potential role in psychiatric and neurodegenerative disorders. It will also highlight the proposed mechanisms of action and the implications thereof for our current understanding of the biomolecular basis of these pathologies. It will conclude with a summary of what we know, but also point out the remaining uncertainties, especially as this relates to the claims in the patent under discussion.

Keywords: AMPA, glutamate, antagonist, epilepsy, schizophrenia, ALS, multiple sclerosis, neuroprotection, anxiety, antiproliferative

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