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Current Respiratory Medicine Reviews


ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Nitrofurantoin Pulmonary Toxicity: A Brief Review

Author(s): Bobbak Vahid and Bernadette M.M. Wildemore

Volume 2, Issue 4, 2006

Page: [439 - 442] Pages: 4

DOI: 10.2174/157339806778777276

Price: $65


Nitrofurantoin is an antimicrobial agent that is commonly used for the treatment of recurrent urinary tract infection. Nitrofurantoin pulmonary toxicity can present as acute, subacute, or chronic respiratory disease. Common manifestations are dry cough, chest pain, dyspnea, and hypoxemia. Skin rash, arthralgia, and abnormal transaminases are occasionally present. Chest imaging shows patchy infiltrates and fibrosis. Treatment includes discontinuing the medication. Although the role of corticosteroids has not been well described, patients with respiratory symptoms or hypoxemia may benefit from a trial of corticosteroid therapy.

Keywords: Nitrofurantoin, drug-induced lung toxicity, organizing pneumonia, pneumonitis

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