Abstract
Receptors that undergo nucleo-cytoplasmic shuttling require microtubules for proper physiologic function. Is it the collapse of microtubules network or simply the arrest of cell cycle in G2/M phase that changes receptors function? The terms of disengagement and the integrity versus dynamics of the microtubules shall guide the ideal drug design.
Keywords: Cytoskeleton, Transcriptional regulation, Nuclear receptors, Drug metabolism
Letters in Drug Design & Discovery
Title: Microtubules and Commuting Receptors
Volume: 3 Issue: 8
Author(s): M. Modriansky, J. Ulrichova and Z. Dvorak
Affiliation:
Keywords: Cytoskeleton, Transcriptional regulation, Nuclear receptors, Drug metabolism
Abstract: Receptors that undergo nucleo-cytoplasmic shuttling require microtubules for proper physiologic function. Is it the collapse of microtubules network or simply the arrest of cell cycle in G2/M phase that changes receptors function? The terms of disengagement and the integrity versus dynamics of the microtubules shall guide the ideal drug design.
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Cite this article as:
Modriansky M., Ulrichova J. and Dvorak Z., Microtubules and Commuting Receptors, Letters in Drug Design & Discovery 2006; 3 (8) . https://dx.doi.org/10.2174/157018006778194718
DOI https://dx.doi.org/10.2174/157018006778194718 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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