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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

K2CO3-Mediated Regioselective Synthesis of Isoxazoles and Pyrazolines

Author(s): Mazaahir Kidwai, Shuchi Kukreja and Ruby Thakur

Volume 3, Issue 2, 2006

Page: [135 - 139] Pages: 5

DOI: 10.2174/157017806775224170

Price: $65


3,5-Diarylisoxazoles and 1,3,5-triarylpyrazolines are synthesized via Michael addition of "hydroxylamine hydrochloride, phenylhydrazine" respectively over chalcones followed by cyclization using K2CO3 as solid support. Reactions are shown to be highly regioselective regardless of the nature of the substituent in the substrates and afforded single isoxazole and pyrazoline isomer in excellent yields.

Keywords: Michael addition, regioselectivity, chalcones, solid support

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