Abstract
Infectious diseases remain a major health problem and cause of death worldwide. A variety of radiopharmaceuticals are used for the imaging of infections and inflammation in the practice of nuclear medicine. Long-term clinical use has shown that the majority of radiolabeled probes cannot distinguish between inflammation and infection. Gallium-67-citrate binds to bacteria, but also to proteins ac-cumulating at both sterile inflammation and bacterial infection sites. Other agents are used to interact with receptors or domains on circu-lating and infiltrating leukocytes or to label them directly. However, these probes cannot distinguish between infection and inflammation because they are not specific to infectious micro-organisms. This review examines the recent developments and applications of radiola-beled specific agents, such as antiviral drugs, antifungal, antibiotics and antimicrobial peptides, to visualize infectious foci by targeting viruses, fungi or bacteria.
Keywords: Radiolabeled antibiotics, antimicrobial peptides, antiviral drugs, technetium-99m-ubiquicidin, scintigraphy, radiopharmaceuticals, inflammation, radiolabeled probes, Gallium-67-citrate, leukocytes
Current Pharmaceutical Design
Title: Development of Specific Radiopharmaceuticals for Infection Imaging by Targeting Infectious Micro-organisms
Volume: 18 Issue: 8
Author(s): Guillermina Ferro-Flores, Blanca E. Ocampo-Garcia and Laura Melendez-Alafort
Affiliation:
Keywords: Radiolabeled antibiotics, antimicrobial peptides, antiviral drugs, technetium-99m-ubiquicidin, scintigraphy, radiopharmaceuticals, inflammation, radiolabeled probes, Gallium-67-citrate, leukocytes
Abstract: Infectious diseases remain a major health problem and cause of death worldwide. A variety of radiopharmaceuticals are used for the imaging of infections and inflammation in the practice of nuclear medicine. Long-term clinical use has shown that the majority of radiolabeled probes cannot distinguish between inflammation and infection. Gallium-67-citrate binds to bacteria, but also to proteins ac-cumulating at both sterile inflammation and bacterial infection sites. Other agents are used to interact with receptors or domains on circu-lating and infiltrating leukocytes or to label them directly. However, these probes cannot distinguish between infection and inflammation because they are not specific to infectious micro-organisms. This review examines the recent developments and applications of radiola-beled specific agents, such as antiviral drugs, antifungal, antibiotics and antimicrobial peptides, to visualize infectious foci by targeting viruses, fungi or bacteria.
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Cite this article as:
Ferro-Flores Guillermina, E. Ocampo-Garcia Blanca and Melendez-Alafort Laura, Development of Specific Radiopharmaceuticals for Infection Imaging by Targeting Infectious Micro-organisms, Current Pharmaceutical Design 2012; 18 (8) . https://dx.doi.org/10.2174/138161212799315821
DOI https://dx.doi.org/10.2174/138161212799315821 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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