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Current Hypertension Reviews

Editor-in-Chief

ISSN (Print): 1573-4021
ISSN (Online): 1875-6506

Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models

Author(s): Natalie O. Karpinich, Samantha L. Hoopes, Daniel O. Kechele, Patricia M. Lenhart and Kathleen M. Caron

Volume 7 , Issue 4 , 2011

Page: [228 - 239] Pages: 12

DOI: 10.2174/157340211799304761

Abstract

Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.

Keywords: Adrenomedullin, angiogenesis, endothelial, lymphangiogenesis, mouse model, permeability, CLR, RAMPs, G-protein coupled receptors, transmembrane accessory proteins, vasodilator


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