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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Peptides in Melanoma Therapy

Author(s): Simone Mocellin

Volume 18, Issue 6, 2012

Page: [820 - 831] Pages: 12

DOI: 10.2174/138161212799277734

Price: $65

Abstract

Peptides derived from tumor associated antigens can be utilized to elicit a therapeutically effective immune response against melanoma in experimental models. However, patient vaccination with peptides - although it is often followed by the induction of melanoma- specific T lymphocytes - is rarely associated with tumor response of clinical relevance. In this review I summarize the principles of peptide design as well as the results so far obtained in the clinical setting while treating cutaneous melanoma by means of this active immunotherapy strategy. I also discuss some immunological and methodological issues that might be helpful for the successful development of peptide-based vaccines.

Keywords: Peptide, melanoma, therapy, immunotherapy, vaccine, diagnosis, vaccination, tumor, T lymphocytes, carcinomas


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