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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Synthesis and Antinociceptive Behaviors of New Methyl and Hydroxyl Derivatives of Phencyclidine

Author(s): A. Ahmadi, M. Kermani, N. Naderi, R. Hajikhani, N.M. Rezaee, M. Javadi and B.N. Niknafs

Volume 19 , Issue 5 , 2012

Page: [763 - 769] Pages: 7

DOI: 10.2174/092986712798992057

Price: $65

Abstract

Phencyclidine (I) and its derivatives show such pharmacological behaviors as analgesic, anticonsulvant, anti-anxiety and antidepressant, while interacting with central nervous system. In this study, new methyl and hydroxyl derivatives of PCP were synthesized and their antinociceptive behaviors in animals were examined by measuring the number of writhing in a writhing test of visceral pain and the pain scores in Formalin test. Compared to control and PCP groups, findings in experimental groups indicated the new synthesized analogues (compounds II, III and V, 10 mg/kg) of PCP were able to produce more analgesic effects in formalin and writhing tests, especially for compound V. It was concluded that the new synthesized derivatives of PCP could substantially and respectively diminish acute and chronic pains.

Keywords: Antinociceptive behaviors, Formalin test, Phencyclidine, Writhing test, pharmacological behaviors, analgesic, anti-anxiety, anticonsulvant, analgesic effects


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