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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

A Review on Biological Activities and Chemical Synthesis of Hydrazide Derivatives

Author(s): R. Narang, B. Narasimhan and S. Sharma

Volume 19 , Issue 4 , 2012

Page: [569 - 612] Pages: 44

DOI: 10.2174/092986712798918789


There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, hormone antagonist, analgesic, anti-inflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and anti-trypanosomal activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazide derivatives that possess varied biological activities.

Keywords: Biological activities, Antimicrobial, Antiviral, Antimycobacterial, Anti-inflammatory, Analgesic, Antioxidant, Anticancer, Antimalarial, Antiarthritis, Anti-trypnosomal, Diuretic, Hydrazide, Hydrazone, Synthesis

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