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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Advancements in Z-DNA: Development of Inducers and Stabilizers for B to Z Transition

Author(s): L. Yang, S. Wang, T. Tian and X. Zhou

Volume 19 , Issue 4 , 2012

Page: [557 - 568] Pages: 12

DOI: 10.2174/092986712798918806

Price: $65


Z-DNA, an active element in genome, has drawn intense interest in chemical and biological field. Its dynamic and transient state makes it challenging to target and regulate. Thus, stabilizing and inducing Z-DNA both in vitro and in vivo is essential, so far, much many efforts have been made in these aspects. However, Z-DNAs induction and stabilization are always performed in high salt condition and sequence-dependent, limited inducers or stabilizers have been achieved with breakthrough in the aspects of real physiological condition and sequence-independence. Herein, we give a review of some typical kinds of Z-DNA inducers and stabilizers, discussing their inducing or stabilizing condition, mechanism, structural relationship and their limitation as well, attempted to get some implication and guidance for Z-DNA inducer or stabilizer design.

Keywords: Z-DNA, inducer, stabilizer, conformational transition, genome, physiological, mechanism, Nucleic acids, macromolecules, topologies

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