Abstract
Aged dogs and humans share complex cognitive and pathological responses to aging. Specifically, dogs develop Alzheimers Disease (AD) like beta-amyloid (Aβ) that are associated with cognitive deficits. Currently, therapeutic approaches to prevent AD are targeted towards reduced production, aggregation and increased clearance of Aβ. The current review discusses cognition and neuropathology of the aging canine model and how it has and continues to be useful in further understanding the safety and efficacy of potential AD prevention therapies targeting A
Keywords: Alzheimer's disease, canine, statins, BACE-1 inhibitors, metal-chelators, A-beta vaccination
Current Neuropharmacology
Title: Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model
Volume: 9 Issue: 4
Author(s): Sarah B. Martin, Amy L.S. Dowling and Elizabeth Head
Affiliation:
Keywords: Alzheimer's disease, canine, statins, BACE-1 inhibitors, metal-chelators, A-beta vaccination
Abstract: Aged dogs and humans share complex cognitive and pathological responses to aging. Specifically, dogs develop Alzheimers Disease (AD) like beta-amyloid (Aβ) that are associated with cognitive deficits. Currently, therapeutic approaches to prevent AD are targeted towards reduced production, aggregation and increased clearance of Aβ. The current review discusses cognition and neuropathology of the aging canine model and how it has and continues to be useful in further understanding the safety and efficacy of potential AD prevention therapies targeting A
Export Options
About this article
Cite this article as:
B. Martin Sarah, L.S. Dowling Amy and Head Elizabeth, Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model, Current Neuropharmacology 2011; 9 (4) . https://dx.doi.org/10.2174/157015911798376217
DOI https://dx.doi.org/10.2174/157015911798376217 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Exploring Shared Pathogenesis of Alzheimer’s Disease and Type 2 Diabetes Mellitus via Co-expression Networks Analysis
Current Alzheimer Research Patent Selections:
Recent Patents on Inflammation & Allergy Drug Discovery Fermented Grape Marc (FGM): Immunomodulating Properties and its Potential Exploitation in the Treatment of Neurodegenerative Diseases
Current Pharmaceutical Design Nifedipine Inhibits the Progression of An Experimentally Induced Cerebral Aneurysm in Rats with Associated Down-Regulation of NF-Kappa B Transcriptional Activity
Current Neurovascular Research Poor Safety and Tolerability Hamper Reaching a Potentially Therapeutic Dose in the Use of Thalidomide for Alzheimer’s Disease: Results from a Double-Blind, Placebo-Controlled Trial
Current Alzheimer Research Perioperative Considerations in Rheumatoid Arthritis Patients
Current Rheumatology Reviews Advances in the Immune Pathogenesis and Treatment of Multiple Sclerosis
Central Nervous System Agents in Medicinal Chemistry Patient Engagement in Randomized Controlled Tai Chi Clinical Trials among the Chronically Ill
Reviews on Recent Clinical Trials Dual-modality Chemo-photodynamic Therapy Using RB and DOX as Anti-cancer Drugs by PAMAM-grafted Hollow Porous Silica Nanoparticles
Current Nanoscience Atomic Force Microscopy Investigation of Ribonuclease A
Protein & Peptide Letters Genetics of Congenital Heart Disease
Current Cardiology Reviews Collective Roles of Molecular Chaperones in Protein Degradation Pathways Associated with Neurodegenerative Diseases
Current Pharmaceutical Biotechnology Pharmacokinetic Considerations of Inhaled Pharmaceuticals for Systemic Delivery
Current Pharmaceutical Design Reduced Alzheimer’s Disease Pathology by St. John’s Wort Treatment is Independent of Hyperforin and Facilitated by ABCC1 and Microglia Activation in Mice
Current Alzheimer Research Therapeutic Targeting of TRPV1 by Resiniferatoxin, from Preclinical Studies to Clinical Trials
Current Topics in Medicinal Chemistry P-Glycoprotein Contributes to Cell Membrane Depolarization of Hippocampus and Neocortex in a Model of Repetitive Seizures Induced by Pentylenetetrazole in Rats
Current Pharmaceutical Design Determinants of Medicine-Taking in Psychiatric Patients
Current Clinical Pharmacology The Search for α-Secretase and its Potential as a Therapeutic Approach to Alzheimers Disease
Current Medicinal Chemistry Review of PI3K/mTOR Inhibitors Entering Clinical Trials to Treat Triple Negative Breast Cancers
Recent Patents on Anti-Cancer Drug Discovery Perioperative Management of Beta Blockers and Other Antiarrhythmic Medications
Current Clinical Pharmacology