Generic placeholder image

Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Structure and Function of Bovine Pancreatic Deoxyribonuclease I

Author(s): Wei-Jung Chen and Ta-Hsiu Liao

Volume 13, Issue 5, 2006

Page: [447 - 453] Pages: 7

DOI: 10.2174/092986606776819475

Price: $65


Bovine pancreatic deoxyribonuclease I (bpDNase), the first DNase discovered, is the best characterized among various types of DNase. A catalytic mechanism has been suggested based on the X-ray structure of the bpDNase-octamer complex. In this review, we will focus on three aspects: 1) the distinctive functions of the two structural calcium atoms; 2) the biological functions of the two disulfides; and 3) the involvement of the N- and C-terminal fragments in the enzyme folding for activity.

Keywords: Deoxyribonuclease, calcium, disulfide, protein folding, chemical modification, site-directed mutagenesis, enzyme mechanism

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy