Abstract
Chromenopyridines constitute a structurally diverse class of compounds with a wide range of bioactivities and increasing presence in drugs. Here we analyze the scope of the synthetic methodology to access this nucleus with emphasis on multicomponent reactions and robust methodologies. Reactivity issues, medicinal applications and other properties are also reviewed.
Keywords: Azines, benzopyran, chromene, coumarin, drug-like scaffolds, heterocycles, multicomponent reactions, privileged structures, pyridine, synthetic methods
Current Medicinal Chemistry
Title: Chromenopyridines: Promising Scaffolds for Medicinal and Biological Chemistry
Volume: 18 Issue: 31
Author(s): L. J. Nunez-Vergara, J. A. Squella, P. A. Navarrete-Encina, E. Vicente-Garcia, S. Preciado and R. Lavilla
Affiliation:
Keywords: Azines, benzopyran, chromene, coumarin, drug-like scaffolds, heterocycles, multicomponent reactions, privileged structures, pyridine, synthetic methods
Abstract: Chromenopyridines constitute a structurally diverse class of compounds with a wide range of bioactivities and increasing presence in drugs. Here we analyze the scope of the synthetic methodology to access this nucleus with emphasis on multicomponent reactions and robust methodologies. Reactivity issues, medicinal applications and other properties are also reviewed.
Export Options
About this article
Cite this article as:
J. Nunez-Vergara L., A. Squella J., A. Navarrete-Encina P., Vicente-Garcia E., Preciado S. and Lavilla R., Chromenopyridines: Promising Scaffolds for Medicinal and Biological Chemistry, Current Medicinal Chemistry 2011; 18 (31) . https://dx.doi.org/10.2174/092986711797535272
DOI https://dx.doi.org/10.2174/092986711797535272 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
QSAR and Docking Studies of N-hydroxy Urea Derivatives as Flap Endonuclease-1 Inhibitors
Current Computer-Aided Drug Design Natural Compounds for Overcoming Multidrug Resistance in Mycobacteria
Recent Patents on Biotechnology Vitamin D in COPD - A Pleiotropic Micronutrient in a Multisystem Disease
Current Respiratory Medicine Reviews Synthesis, <i>In silico</i> and <i>In vitro</i> Analysis of Hydrazones as Potential Antituberculosis Agents
Current Computer-Aided Drug Design Dried Blood Spots: A New Tool for Tuberculosis Treatment Optimization
Current Pharmaceutical Design Subject Index To Volume 3
Current Drug Delivery Lipid Matrix Nanoparticles: Pharmacokinetics and Biopharmaceutics
Current Nanoscience Fabrication and Characterization of Chitosan Nanoparticles: A controlled Release Approach Towards Tuberculosis Chemotherapy
Drug Delivery Letters Synthesis of Marine Natural Products with Antimalarial Activity
Mini-Reviews in Medicinal Chemistry Antimycobacterial Activity of Quaternary Pyridinium Salts and Pyridinium N-oxides - Review
Current Pharmaceutical Design In vitro Synthesis, Structure Elucidation, and Antioxidant Properties of Platinum(IV)-hydrazide Complexes: Molecular Modeling of Free- Hydrazides Suggested as Potent Lipoxygenase Inhibitor
Medicinal Chemistry Zebrafish Model in Drug Safety Assessment
Current Pharmaceutical Design Synthesis, Biological Activity of Thiazolidinones Bearing Indoline Moiety and Isatin Based Hybrids
Mini-Reviews in Organic Chemistry 3D-QSAR and Molecular Docking Studies of Pyrazole Derivatives as Inhibitors of Enoyl Acyl Carrier Protein Reductase from Mycobacterium tuberculosis
Letters in Drug Design & Discovery Advance Synthetic Approaches to 1,2,3-triazole Derived Compounds: State of the Art 2004-2020
Current Organocatalysis Benzocaine: Review on a Drug with Unfold Potential
Mini-Reviews in Medicinal Chemistry Itraconazole Induced Congestive Heart Failure, A Case Study
Current Drug Safety New Potential Pharmaceutical Applications of Hypericum Species
Mini-Reviews in Medicinal Chemistry Vesicovaginal Fistula
Current Women`s Health Reviews Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents
Letters in Drug Design & Discovery