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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Optimizing Scale Up Yield to Pyridazines and Fused Pyridazines

Author(s): Saleh Mohamed Al-Mousawi, Moustafa Sherief Moustafa, Ismail Abdelshafy Abdelhamid and Mohamed Hilmy Elnagdi

Volume 15, Issue 19, 2011

Page: [3503 - 3513] Pages: 11

DOI: 10.2174/138527211797374760

Price: $65


Approaches for the preparation of pyridazines and fused pyridazines are reviewed. Some corrections about errors in the old literature are given and discussed. The %yields of selected examples are optimized.

Keywords: Pyridazines, synthesis, % yield optimization, heterocyclic nucleus, spectroscopic data, lone pair delocalization, cf. resonance, reactions of Mannich bases, Vilsmeier reactions, HMBC data, benzenediazonium chloride, aromatic diazonium salts, malononitrile, phthalazines

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