Abstract
A kind of univariate calibration, net analyte signal combined with standard addition (NAS-SAM) is presented for determination of Guaifenesin, Pseudoephedrine and Chlorpheniramine in the presence of each other by spectrophotometry. The method has both the advantages of the standard addition method and net analyte signal which enables the extraction of information concerning a certain analyte from spectra of multi-component mixtures. The use of full spectrum to calculate the net analyte signal vector and also no requirement of calibration and prediction steps are the most important advantages of NAS-SAM. The simultaneous determination of Guaifenesin, Pseudoephedrine and Chlorpheniramine was performed in Britton-Robinson buffer (pH 9). Three pharmaceutical compounds were determined in concentration range of 0.5-100 μmol L-1 In this work, the method of NAS-SAM has been used for the determination of guaifenesin, pseudoephedrine and chlorpheniramine in some ternary mixtures and cough syrups with satisfactory results.
Keywords: Chemometrics, Chlorpheniramine, Correlation, Full Spectrum, Guaifenesin, NAS-SAM, Orthogonalization, Overlapping spectra, Pseudoephedrine, Syrups
Current Pharmaceutical Analysis
Title: The Use of Net Analyte Signal Aspect in Univariate Calibration for Simultaneous Determination of Guaifenesin, Pseudoephedrine and Chlorpheniramine in Cough Syrup Formulations
Volume: 8 Issue: 1
Author(s): Reza Hajian and Ali Karamian
Affiliation:
Keywords: Chemometrics, Chlorpheniramine, Correlation, Full Spectrum, Guaifenesin, NAS-SAM, Orthogonalization, Overlapping spectra, Pseudoephedrine, Syrups
Abstract: A kind of univariate calibration, net analyte signal combined with standard addition (NAS-SAM) is presented for determination of Guaifenesin, Pseudoephedrine and Chlorpheniramine in the presence of each other by spectrophotometry. The method has both the advantages of the standard addition method and net analyte signal which enables the extraction of information concerning a certain analyte from spectra of multi-component mixtures. The use of full spectrum to calculate the net analyte signal vector and also no requirement of calibration and prediction steps are the most important advantages of NAS-SAM. The simultaneous determination of Guaifenesin, Pseudoephedrine and Chlorpheniramine was performed in Britton-Robinson buffer (pH 9). Three pharmaceutical compounds were determined in concentration range of 0.5-100 μmol L-1 In this work, the method of NAS-SAM has been used for the determination of guaifenesin, pseudoephedrine and chlorpheniramine in some ternary mixtures and cough syrups with satisfactory results.
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Cite this article as:
Hajian Reza and Karamian Ali, The Use of Net Analyte Signal Aspect in Univariate Calibration for Simultaneous Determination of Guaifenesin, Pseudoephedrine and Chlorpheniramine in Cough Syrup Formulations, Current Pharmaceutical Analysis 2012; 8 (1) . https://dx.doi.org/10.2174/157341212798995449
DOI https://dx.doi.org/10.2174/157341212798995449 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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