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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Metallodendrimers and Dendrimer Nanocomposites

Author(s): Yi-Hsuan Tang, Adela Ya-Ting Huang, Po-Yu Chen, Hui-Ting Chen and Chai-Lin Kao

Volume 17, Issue 22, 2011

Page: [2308 - 2330] Pages: 23

DOI: 10.2174/138161211797052367

Price: $65

Abstract

Dendrimers are polymeric compounds with highly branched structures and functionally tunable peripheral groups. Because of their low polydispersity, high degree of molecular uniformity, and precisely controlled structure, dendrimers are excellent models for demonstrating a variety of biological activities. With the attachment of metals ions and/or metals, metallodendrimers or dendrimer nanocomposites, respectively, provide diverse characters for a variety of applications. Functionalization with additional moieties, such as targeted peptides or chromophores, yields metallodendrimers that can find powerful applications and exceed the capabilities of nondendritic molecules or small molecule analogs. This review introduces the background of metallodendrimers and dendrimer nanocomposites. Biomedical applications of metallodendrimers and dendrimer nanocomposites will be discussed, including biomimetic catalysts, imaging contrast agents (especially for MRI imaging), or biomedical sensors and therapeutic agents.

Keywords: Metallodendrimers, dendrimer nanocomposites, biomimetic catalysts, contrast agents, biosensors, therapeutic agents, thermodynamic effects, epoxidation reaction, folate, magnetic resonance imaging (MRI)


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