Abstract
Quantum dot (QD) has been extensively investigated as a nanoprobe to replace conventional organic dyes due to its unique optical properties. However, nanotoxicity of QD greatly hampers its biomedical applications, particularly in in vivo imaging. It is critical to functionalize QD and/or composite QD with other functional materials for biocompatibility, multifunction and expanded applications. In this review, advances of QD-based nanocomposites are addressed with emphasis of their synthesis, fundamental understanding and applications in biosensor, multimodal imaging, drug delivery, diagnostics and cancer therapy. Some specific QD-based bionanosystems and future development directions are also discussed.
Keywords: Biomedicine, bioimaging, biosensor, cancer therapy, drug delivery, fluorescence, multifunction, multimodal imaging, nanocomposite, quantum dot
Current Medicinal Chemistry
Title: Quantum Dot-Based Nanocomposites for Biomedical Applications
Volume: 18 Issue: 23
Author(s): Z. S. Lu and C. M. Li
Affiliation:
Keywords: Biomedicine, bioimaging, biosensor, cancer therapy, drug delivery, fluorescence, multifunction, multimodal imaging, nanocomposite, quantum dot
Abstract: Quantum dot (QD) has been extensively investigated as a nanoprobe to replace conventional organic dyes due to its unique optical properties. However, nanotoxicity of QD greatly hampers its biomedical applications, particularly in in vivo imaging. It is critical to functionalize QD and/or composite QD with other functional materials for biocompatibility, multifunction and expanded applications. In this review, advances of QD-based nanocomposites are addressed with emphasis of their synthesis, fundamental understanding and applications in biosensor, multimodal imaging, drug delivery, diagnostics and cancer therapy. Some specific QD-based bionanosystems and future development directions are also discussed.
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Cite this article as:
S. Lu Z. and M. Li C., Quantum Dot-Based Nanocomposites for Biomedical Applications, Current Medicinal Chemistry 2011; 18 (23) . https://dx.doi.org/10.2174/092986711796642634
DOI https://dx.doi.org/10.2174/092986711796642634 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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