Role of the Non-Receptor Tyrosine Kinase Fes in Cancer

Title: Role of the Non-Receptor Tyrosine Kinase Fes in Cancer

Volume: 18 Issue: 19

Author(s): F. Condorelli, E. Stec-Martyna, J. Zaborowska, L. Felli, I. Gnemmi, M. Ponassi and C. Rosano

Affiliation:

• Nanobiotechnologies, National Institute for Cancer Research (IST) Largo R. Benzi 10, 16132 Genova, Italy.,Italy

Keywords: Fes kinase, non receptor tyrosine kinase, structure based drug design, protein structure, protein crystallography

Abstract: Non receptor protein tyrosine kinases are targets in the treatment of a number of diseases. This review focuses on the role of Fes tyrosine kinase and on the design of inhibitors of this protein. Fes and its homologously related protein Fer are the only two members of a distinct class of non receptor tyrosine kinases and they seem to play a role in cytoskeletal rearrangements and inside-out signalling associated with receptor-ligand, cell-matrix and cell-cell interactions. The knowledge of the three dimensional structure of this protein, in fact, has informed drug design, while at the same time it has helped to shed some light on the molecular mechanism at the basis of kinase activation and functions.

Cite this article as:

Condorelli F., Stec-Martyna E., Zaborowska J., Felli L., Gnemmi I., Ponassi M. and Rosano C., Role of the Non-Receptor Tyrosine Kinase Fes in Cancer, Current Medicinal Chemistry 2011; 18(19) . https://dx.doi.org/10.2174/092986711796150522