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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Protein Kinase Homology Models: Recent Developments and Results

Author(s): T. Tuccinardi and Adriano Martinelli

Volume 18 , Issue 19 , 2011

Page: [2848 - 2853] Pages: 6

DOI: 10.2174/092986711796150441

Price: $65

Abstract

Protein kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families, and knowledge of their three-dimensional structure could be of great help in the rational design of specific ligands. However, only about one quarter of human protein kinase structures has been experimentally defined; thus, kinase homology modeling techniques have been widely diffused. In this review, the most recent kinase homology models are reported, together with the most recent approaches and the main validation methods.

Keywords: Kinase, homology modeling, virtual screening, docking, kinase inhibitors


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