Protein Kinase Homology Models: Recent Developments and Results

Title: Protein Kinase Homology Models: Recent Developments and Results

Volume: 18 Issue: 19

Author(s): T. Tuccinardi and Adriano Martinelli

Affiliation:

• Dipartimento di Scienze Farmaceutiche, Universita di Pisa, via Bonanno 6, 56126 Pisa, Italy.,Italy

Keywords: Kinase, homology modeling, virtual screening, docking, kinase inhibitors

Abstract: Protein kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families, and knowledge of their three-dimensional structure could be of great help in the rational design of specific ligands. However, only about one quarter of human protein kinase structures has been experimentally defined; thus, kinase homology modeling techniques have been widely diffused. In this review, the most recent kinase homology models are reported, together with the most recent approaches and the main validation methods.

Cite this article as:

Tuccinardi T. and Martinelli Adriano, Protein Kinase Homology Models: Recent Developments and Results, Current Medicinal Chemistry 2011; 18(19) . https://dx.doi.org/10.2174/092986711796150441