Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Aluminum Vaccine Adjuvants: Are they Safe?

Author(s): L. Tomljenovic and C. A. Shaw

Volume 18, Issue 17, 2011

Page: [2630 - 2637] Pages: 8

DOI: 10.2174/092986711795933740

Price: $65

Abstract

Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical sciences understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted. Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. In particular, aluminum in adjuvant form carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. In our opinion, the possibility that vaccine benefits may have been overrated and the risk of potential adverse effects underestimated, has not been rigorously evaluated in the medical and scientific community. We hope that the present paper will provide a framework for a much needed and long overdue assessment of this highly contentious medical issue.

Keywords: Aluminum adjuvants, adjuvant safety, autoimmunity, autism, Gulf War Syndrome, multiple sclerosis, macrophagic myofasciitis, neurotoxicity, seizures, Th2 immune response, vaccines


Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy