Abstract
The establishment of neural connectivity implicates tight regulation of the intracellular signaling pathways mediated by axon guidance molecules. The Rho family of small GTPases, in particular Rho, Rac, and Cdc42, are important regulators of the cytoskeleton in neuronal cells acting, downstream of most, if not all, guidance cue receptors. Furthermore, recent studies using in vivo knockout mouse models provide new evidence of the primary role played by Rho GTPase signaling during the development of the nervous system. Here, we review our recent understanding of Rho GTPase signaling in response to classical axon guidance cues in mammalian cells. We also describe how in vivo knockout mouse models have been useful to implicate Rho GTPase signaling during the formation of the nervous system. Finally, we present several lines of evidence showing the involvement of Rho GTPase signaling in the development and progression of neurodegenerative diseases.
Keywords: Rho GTPases, axon guidance, knockout mouse models, neurodegenerative diseases, ephrins, semaphorins, netrin, synaptic plasticity, neuronal migration
Current Drug Targets
Title: Implication of Rho GTPases in Neurodegenerative Diseases
Volume: 12 Issue: 8
Author(s): Judith Antoine-Bertrand, Josee-France Villemure and Nathalie Lamarche-Vane
Affiliation:
Keywords: Rho GTPases, axon guidance, knockout mouse models, neurodegenerative diseases, ephrins, semaphorins, netrin, synaptic plasticity, neuronal migration
Abstract: The establishment of neural connectivity implicates tight regulation of the intracellular signaling pathways mediated by axon guidance molecules. The Rho family of small GTPases, in particular Rho, Rac, and Cdc42, are important regulators of the cytoskeleton in neuronal cells acting, downstream of most, if not all, guidance cue receptors. Furthermore, recent studies using in vivo knockout mouse models provide new evidence of the primary role played by Rho GTPase signaling during the development of the nervous system. Here, we review our recent understanding of Rho GTPase signaling in response to classical axon guidance cues in mammalian cells. We also describe how in vivo knockout mouse models have been useful to implicate Rho GTPase signaling during the formation of the nervous system. Finally, we present several lines of evidence showing the involvement of Rho GTPase signaling in the development and progression of neurodegenerative diseases.
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Cite this article as:
Antoine-Bertrand Judith, Villemure Josee-France and Lamarche-Vane Nathalie, Implication of Rho GTPases in Neurodegenerative Diseases, Current Drug Targets 2011; 12 (8) . https://dx.doi.org/10.2174/138945011795906543
DOI https://dx.doi.org/10.2174/138945011795906543 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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