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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Recent Developments in the Synthesis and Biological Activity of Muramylpeptides

Author(s): K. Dzierzbicka, A. Wardowska and P. Trzonkowski

Volume 18 , Issue 16 , 2011

Page: [2438 - 2451] Pages: 14

DOI: 10.2174/092986711795843173

Price: $65

Abstract

Derivatives of muramyl dipeptide (MDP) are considered as immunostimulants and adjuvants in the immunotherapy of cancer and infections. The interest in these compounds is mainly related to a high variety of their structure and biological properties. Here, we describe the synthesis and biological activity of several recently developed classes of MDP analogues. We also report potential of these analogues in the treatment of cancer and infectious diseases in experimental systems and cancer patients.

Keywords: Muramyl dipeptide, MDP, MDP analogues, adjuvant, synthesis, cancer immunotherapy, innate immunity


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