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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Branched Peptides for the Modulation of Protein-Protein Interactions: More Arms are Better than One?

Author(s): M. Ruvo, A. Sandomenico, L. Tudisco and S. De Falco

Volume 18 , Issue 16 , 2011

Page: [2429 - 2437] Pages: 9

DOI: 10.2174/092986711795843191

Price: $65


Combinatorial peptide libraries from synthetic or biological sources have been largely used in the last two-decades with the aim of identifying bioactive peptides that specifically bind proteins and modulate their interactions with other protein partners. Differently from biological libraries, synthetic methods allow the development of different kinds of libraries based on two main characteristics: i) the use of building blocks and chemical bonds different from those naturally occurring and ii) the possibility of designing scaffolds with non-linear shapes, as cyclic and branched structures. These two features, alone or in combination, have increased the chemical and structural diversity of peptide libraries expanding the offer of collections for the screenings. Here we describe our and other experiences with branched peptides and the results obtained in the last fifteen years. These clearly indicate how the use of short multimerized peptides can represent a successful approach for different applications ranging from affinity chromatography to the modulation of protein-protein interactions in different biological contexts.

Keywords: Multimeric peptides, combinatorial peptide library, nterleukin-6, immunoglobulin purification, PAM (Protein A Mimetic), Fc receptor, VEGFR-1, Cripto, Hepatitis B virus, Squamous Cell Carcinoma Antigen 1, Neurotensin, TNFα, MAP (Mulptiple Antigen Peptide)

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