Generic placeholder image

Current Medical Imaging


ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Molecular Imaging with Small Animal PET/CT

Author(s): Tina Binderup, Henrik H. El-Ali, Valentina Ambrosini, Dorthe Skovgaard, Mette Munk Jensen, Fan Li, Birger Hesse, Jesper Tranekjær Jørgensen and Andreas Kjær

Volume 7, Issue 3, 2011

Page: [234 - 247] Pages: 14

DOI: 10.2174/157340511796411221

Price: $65


Small animal positron emission tomography (PET) and computer tomography (CT) is an emerging field in preclinical imaging. High quality, state-of-the-art instruments are required for full optimization of the translational value of the small animal studies with PET and CT. However, with this achieved the possibilities are numerous and the role of preclinical imaging crucial for a prompt movement from bench to bedside. Several new tracers are under preclinical and clinical evaluation and most are directed at central aspects of tumor biology. We hereby present some of the recent advances in this field of small animal molecular imaging with special emphasis on the targets for tissue characterization in tumor biology such as hypoxia, proliferation and cancer specific over-expression of receptors. The added value of applying CT imaging for anatomical localization and tumor volume measurements is also described. In addition, the noninvasive nature of molecular imaging and the targets of these promising new tracers are attractive for other research areas as well, although these fields are much less explored. We present an example of an interesting research field with the application of small animal PET/CT for studies of muscle and tendon in exercise models.

Keywords: MicroPET, Microct, tissue characterization, molecular imaging

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy