Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Regulation of Expression and Function of IDO in Human Dendritic Cells

Author(s): A. Heitger

Volume 18 , Issue 15 , 2011

Page: [2222 - 2233] Pages: 12

DOI: 10.2174/092986711795656018

Price: $65

Abstract

In the human immune system, IDO expression and activity (IDO competence), are preferentially found in the antigenpresenting cell population, of which dendritic cells (DCs) represent an essential part. As will be comprehensively reviewed, IDO competence in human DCs, in general, is induced by molecules such as interferon-γ, which otherwise initiate immunity. IDO activity therefore, can be interpreted as a negative feedback pathway that limits uncontrolled immune responses. Because of its potent immunosuppressive effects (down-regulation of T cell responses or the expansion of T cell regulatory activity), IDO competence in human DCs is tightly regulated, at the transcriptional, translational and post-translational levels. I will critically discuss the experimental prerequisites and limits of attributing IDO competence to a mechanism of immunosuppression and examine, whether IDO competence itself can be viewed as mediating immunosuppression, or as representing one component among other immunosuppressive factors, involved in tolerogenic function of DCs. Finally, the newly emerging concepts of manipulating IDO competence as a therapy for either augmenting immune responses, such as in cancer, or down-regulating immune responses, such as in transplantation, will be summarized.

Keywords: Dendritic cells, human, immune response, indoleamine 2,3-dioxygenase, kynurenines, tryptophan metabolism, IDO, interferon, immunosuppressive, mediating immunosuppression


Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy