Abstract
Drug-induced mitochondrial dysfunction is a contributor to both late-stage compound attrition and post-market drug withdrawals. This review outlines the mechanisms which lead to drug-induced mitochondrial dysfunction and discusses the tremendous advances that have been made in the development of in vitro methods to identify mitochondrial impairment. Potentially useful animal models and in vivo methods to detect drug-induced mitochondrial impairment are also discussed.
Keywords: Mitochondrial dysfunction, oxidative phosphorylation, organ toxicity, mitochondrial diseases, drug safety, bioenergetics, mutation, metabolomics, dyslipidemia, NSAID, water, synthesis, organic
Current Drug Targets
Title: Investigating Mitochondrial Dysfunction to Increase Drug Safety in the Pharmaceutical Industry
Volume: 12 Issue: 6
Author(s): Sashi Nadanaciva and Yvonne Will
Affiliation:
Keywords: Mitochondrial dysfunction, oxidative phosphorylation, organ toxicity, mitochondrial diseases, drug safety, bioenergetics, mutation, metabolomics, dyslipidemia, NSAID, water, synthesis, organic
Abstract: Drug-induced mitochondrial dysfunction is a contributor to both late-stage compound attrition and post-market drug withdrawals. This review outlines the mechanisms which lead to drug-induced mitochondrial dysfunction and discusses the tremendous advances that have been made in the development of in vitro methods to identify mitochondrial impairment. Potentially useful animal models and in vivo methods to detect drug-induced mitochondrial impairment are also discussed.
Export Options
About this article
Cite this article as:
Nadanaciva Sashi and Will Yvonne, Investigating Mitochondrial Dysfunction to Increase Drug Safety in the Pharmaceutical Industry, Current Drug Targets 2011; 12 (6) . https://dx.doi.org/10.2174/138945011795528985
DOI https://dx.doi.org/10.2174/138945011795528985 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cardiovascular Disease in Patients with Diabetic Nephropathy
Current Molecular Medicine Real-time Detection of Aortic Valve in Echocardiography using Convolutional Neural Networks
Current Medical Imaging Ivabradine: A Current Overview
Current Clinical Pharmacology Sex Differences in Biomarkers for Predicting Cardiovascular and Coronary Events
Current Vascular Pharmacology Sympathetic Nervous System in Patients with Sleep Related Breathing Disorders
Current Hypertension Reviews Genetic Privacy in Sports: Clearing the Hurdles
Recent Patents on DNA & Gene Sequences Role of Heme Oxygenase-1 in Cardiovascular Function
Current Pharmaceutical Design High-output Cardiac Failure: A Forgotten Phenotype in Clinical Practice
Current Cardiology Reviews Protein Misfolding Diseases and Therapeutic Approaches
Current Protein & Peptide Science MCP-1/CCL2 as a Therapeutic Target in Myocardial Infarction and Ischemic Cardiomyopathy
Inflammation & Allergy - Drug Targets (Discontinued) Spectral Features and In Vitro Antioxidant Study of Nanoscale Solid Dispersions of Different Sizes of Coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) Prepared by Heat Melt and High-pressure Homogenization Method
Current Nanoscience Physiological and Pathological Role of TRPV1, TRPV2 and TRPV4 Channels in Heart
Current Cardiology Reviews Phosphorylated and O-GlcNAc Modified IRS-1 (Ser1101) and -2 (Ser1149) Contribute to Human Diabetes Type II
Protein & Peptide Letters Enzyme Replacement Therapy in Fabry Disease: Influence on Cardiac Manifestations
Current Medicinal Chemistry Microvascular Function/Dysfunction Downstream a Coronary Stenosis
Current Pharmaceutical Design Cardiac Innervation and Sudden Cardiac Death
Current Cardiology Reviews Electrocardiographic Abnormalities in Thalassemia Patients with Heart Failure
Cardiovascular & Hematological Disorders-Drug Targets Editorial: Modifying Cardiovascular Risk Factors: Acquired Topics and Emerging Concepts
Current Pharmaceutical Design Human Tissue Kallikrein: A New Bullet for the Treatment of Ischemia
Current Pharmaceutical Design Preface
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry