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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The 21st Century Form of Vitamin E - Tocotrienol

Author(s): Jayeeta Bardhan, Runu Chakraborty and Utpal Raychaudhuri

Volume 17, Issue 21, 2011

Page: [2196 - 2205] Pages: 10

DOI: 10.2174/138161211796957472

Price: $65

Abstract

Vitamin E family constitutes of tocopherol and tocotrienol. Each form has several isomers: alpha,beta, gamma, delta, desmo and didesmo. Although tocopherol is known much earlier, tocotrienol has been discovered more recently.Tocotrienol has higher antioxidant potential than tocopherol. Research shows that tocotrienol can inhibit the induced oxidative damage to lipids and proteins. Cholesterol biosynthesis pathway requires HMG Co A reductase. Tocotrienol degrades HMG Co A reductase protein and in turn lowers cholesterol synthesis. Tocotrienol can reverse ischemia-reperfusion which mediates cardiac dysfunction and induces c-Src protein expression. Tocotrienol prevents oxytosis and offers protection against Alzheimers disease, Parkinsons disease, Hungtingtons disease. Tocotrienol exerts anticancer property through cell cycle arrest, induction of apoptosis, inhibition of angiogenesis; antitumor activity. Tocotrienol also possesses anti-inflammatory, antidiabetic, antiadipogenic and antiatherogenic effect.

Keywords: Antioxidant, tocotrienol, signaling, cholesterol, cancer, dextrorotatory, osteoclastic activity, cardioprotection, oncogenesis, angiogenesis


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