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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

The Delivery of Biologically Active (Therapeutic) Peptides and Proteins into Cells

Author(s): M. Grdisa

Volume 18 , Issue 9 , 2011

Page: [1373 - 1379] Pages: 7

DOI: 10.2174/092986711795029591

Price: $65


Biologically active peptides and proteins have a great potential to act as targeted drug therapies in the treatment of a variety of diseases, including cancer. However, their use in vivo is limited by their low stability and cell permeability. Thus, it is necessary to develop efficient and safe peptide/protein delivery systems that can overcome these problems and increase a therapy's bioavailability. The search for promising vectors has led to the use of compounds called cell-penetrating peptides or protein transduction domains. The cellpenetrating peptides, as effective transporter, are utilized to enhance uptake of various biologically active peptide/protein cargos upon fusion or attachment to its sequences. Cell-penetrating peptides have been the subject of investigation of many researchers, however this review only focuses on the arginine-rich and amphipathic carriers and their potential therapeutic use.

Keywords: Drug delivery, protein transduction, TAT, amphipathic peptides, CPP, CTP, cell, liposome, electroporation, plasma

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