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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Analysis of Molecular Targets of Mycobacterium tuberculosis by Analytical Ultracentrifugation

Author(s): J. C. Borges and C. H.I. Ramos

Volume 18 , Issue 9 , 2011

Page: [1276 - 1285] Pages: 10

DOI: 10.2174/092986711795029537

Price: $65


The interest in analytical ultracentrifugation (AUC) to analyze protein structural parameters and interactions has increased in the past decades as a result of several developments on new generation instrumentation and data analysis tools. In this article, we review AUC principles and applications to study proteins, emphasizing molecular targets of Mycobacterium tuberculosis.

Keywords: Analytical ultracentrifugation, protein folding, Mycobacterium tuberculosis, protein structure-function, anti-tuberculosis agents, high centrifugal force, hydrodynamic parameters, sedimentation, colloids, macromolecules

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